High Throughput Experimentation Chemist
Guidehouse
2 - 5 years
Maryland
Posted: 23/05/2026
Job Description
Job Family:
Scientist
Travel Required:
Clearance Required:
What You Will Do:
We are seeking a High Throughput Experimentation Chemist to support reaction optimization and analog synthesis efforts aimed at standardizing and improving these workflows. This is a full-time, on-site opportunity in Rockville, MD.
Perform chemical and biochemical reactions and appropriate analytical analyses.
Collect and review data; analyze and interpret data and results.
Execute chemical synthesis and optimization of small molecule probes for use in biological research.
Purify compounds submitted by chemists.
Devise synthetic routes to target molecules; produce 10-100 member libraries with acceptable purity and deliver quantities to support biological assays.
Synthesize and optimize chemical probes for potency and solubility.
Formulate chemistry plans for the development of soluble, potent, selective small molecule probes of biological function; analyze samples using validated analytical methods for ongoing studies.
Validate analysis methods for the quantification of cell kinetics.
Work with staff in identity, purity, and stability analysis.
Perform bulk-synthesis, purification, and formulation efforts for advanced testing in animal models.
Analyze samples using validated analytical methods for ongoing studies.
Perform organic synthesis in support of the medicinal chemistry program.
Prepare reports to include a summary of the samples (experimental or clinical), the modifications measured, and the results validated; write papers and abstracts detailing research efforts and results for publication in peer-reviewed journals.
What You Will Need:
Master’s degree in chemistry.
Minimum TWO (2) years of chemical analysis experience in a laboratory setting.
Demonstrated experience with common analytical chemistry techniques such as High-Performance Liquid Chromatography (HPLC) and/ or Mass Spectrometry (MS).
Proven ability to document findings as shown through items such as peer reviewed publications, conference presentations/posters, or similar activities.
Must be able to obtain and maintain a Federal or DoD Public Trust. Candidates must receive approved adjudication of their Public Trust prior to onboarding with Guidehouse. Candidates with an active Public Trust or existing suitability are preferred.
What Would Be Nice To Have:
Experience with affinity-chromatography very beneficial.
Experience using Microsoft Office Suite.
Strong oral and verbal communication skills.
Able to maintain a functional lab environment.
What We Offer:
Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.
Benefits include:
Medical, Rx, Dental & Vision Insurance
Personal and Family Sick Time & Company Paid Holidays
Parental Leave
401(k) Retirement Plan
Group Term Life and Travel Assistance
Voluntary Life and AD&D Insurance
Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts
Transit and Parking Commuter Benefits
Short-Term & Long-Term Disability
Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities
Employee Referral Program
Corporate Sponsored Events & Community Outreach
Care.com annual membership
Employee Assistance Program
Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)
Position may be eligible for a discretionary variable incentive bonus
About Guidehouse
Guidehouse is an Equal Opportunity Employer–Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.
Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.
If you have visited our website for information about employment opportunities, or to apply for a position, and you require an accommodation, please contact Guidehouse Recruiting at 1-571-633-1711 or via email at RecruitingAccommodation@guidehouse.com. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation.
All communication regarding recruitment for a Guidehouse position will be sent from Guidehouse email domains including @guidehouse.com or guidehouse@myworkday.com. Correspondence received by an applicant from any other domain should be considered unauthorized and will not be honored by Guidehouse. Note that Guidehouse will never charge a fee or require a money transfer at any stage of the recruitment process and does not collect fees from educational institutions for participation in a recruitment event. Never provide your banking information to a third party purporting to need that information to proceed in the hiring process.
If any person or organization demands money related to a job opportunity with Guidehouse, please report the matter to Guidehouse’s Ethics Hotline. If you want to check the validity of correspondence you have received, please contact recruiting@guidehouse.com. Guidehouse is not responsible for losses incurred (monetary or otherwise) from an applicant’s dealings with unauthorized third parties.
Guidehouse does not accept unsolicited resumes through or from search firms or staffing agencies. All unsolicited resumes will be considered the property of Guidehouse and Guidehouse will not be obligated to pay a placement fee.
About Company
Guidehouse is a leading global provider of consulting services to the public sector and commercial markets, with broad capabilities in management, technology, and risk consulting. By combining our public and private sector expertise, we help clients address their most complex challenges and navigate significant regulatory pressures focusing on transformational change, business resiliency, and technology-driven innovation. Across a range of advisory, consulting, outsourcing, and digital services, we create scalable, innovative solutions that help our clients outwit complexity and position them for future growth and success._x000d_ _x000d_ The company has more than 16,000 professionals in over 55 locations globally. Guidehouse is led by seasoned professionals with proven and diverse expertise in traditional and emerging technologies, markets, and agenda-setting issues driving national and global economies.
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